Hanyang University
222 Wangsimniro, Seungdong-Gu
Seoul, 04763
Republic of Korea
Office: +82-2-2220-2540
Lab: +82-2-2220-4780
e-mail: jchoi75@hanyang.ac.kr

Laboratory of Pathophysiology
Hanyang University

Jae-Hoon Choi
DVM, PhD.
Department of Life Science, Hanyang University, Seoul, Republic of Korea
We are studying the innate immune cells including dendritic cells and macrophages in cardiovascular system, and then figuring out the immunological features and anatomical locations in healthy aortas and cardiac valves and also the local functions of each cell type during hyperlipidemia.



Selected Publications
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia.
Nat Commun. 2022 Sep 17;13(1):5461. Selected as Featured Article
Characteristics of plaque lipid-associated macrophages and their possible roles in the pathogenesis of atherosclerosis. Curr Opin Lipidol.
2022 Oct 1;33(5):283-288.
Cell Mol Gastroenterol Hepatol. 2021 Apr 21;12(2):715-739.
Aggravation of atherosclerosis by pulmonary exposure to indium oxide nanoparticles. Nanotoxicology. 2020 Apr;14(3):355-371.
Response by Kim and Choi to Letter Regarding Article, "Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models". Circ Res. 2018 Nov 9;123(11):e50.
Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy.
Anim Cells Syst (Seoul). 2018 Sep 28;22(6):390-399.
Transcriptome analysis reveals non-foamy rather than foamy plaque macrophages are pro-inflammatory in atherosclerotic murine models.
Circ Res., 2018 Oct 26;123(10):1127-1142.
Isolation and Characterization of Aortic Dendritic Cells and Lymphocytes in Atherosclerosis. Methods Mol Biol. 2017;1559:419-437.
Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis. PLoS One. 2016 Jun 9;11(6):e0156979.
Aortic Plasmacytoid Dendritic Cells Elicit a Protective Immune Response Against Atherosclerosis. Cell Metab. 2016 May 10;23:852-866.
Involvement of Immune Cell Network in Aortic Valve Stenosis: Communication between Valvular Interstitial Cells and Immune Cells.
Immune Netw. 2016 Feb;16(1):26-32.
Retnla overexpression attenuates allergic inflammation of the airway. PLoS One, 2014 Nov 21;9(11):e112666.
KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model. Exp Mol Med. 2012;44(12):733-9. *equal contribution
Dendritic cells and regulatory T cells in atherosclerosis. Mol Cells. 2012;34(4):341-7.
~2011 (First author)
Flt3 signaling-dependent dendritic cells protect against atherosclerosis. Immunity. 2011 Nov 23;35(5):819-31.
-Preview by Bedouli S and Heath WR. A local role for CD103+ dendritic cells in atherosclerosis. Immunity 23:665-7 (2011)
-Article identified as outstanding by F1000’s
-Highlighted by Ralph M. Steinman: Decisions About Dendritic Cells: Past, Present and Future. Annu. Rev. Immunol. 30:1-22 (2012)
2.5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion. Exp Mol Med. 2011 Aug 31;43(8):471-8.
Dendritic cells within human anti-human DEC205 monoclonal antibody. Blood. 2010 Nov 11;116(19):3828-38.
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice.
Atherosclerosis. 2010 Sep;212(1):146-52.
CD137 (4-1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice. Circulation. 2010;121(9):1124-1133.
Identification of antigen presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med. 2009;206(3):497-505. (Cover paper of March issue)
